Genetic dissection of signaling pathways important in breast development and breast cancer

Breast cancer strikes one out of eight women in Switzerland. A woman’s risk to get breast cancer is linked to her reproductive history. While early pregnancies have a protective effect, cancer risk increases with the number of menstrual cycles a woman experiences prior to her first pregnancy. Although it is well established that the female sex hormones estrogen, progesterone and prolactin control breast development and have an important role in breast carcinogenesis, the mechanisms by which they exert their effects are poorly understood. Our goal is to understand how hormones interact with developmental signaling pathways in the breast to control growth and differentiation and how they contribute to breast cancer development. We seek to translate the insights into novel approaches to prevent and treat breast cancer. More

Prof. Cathrin Brisken

 

Selected Publications :

A preclinical Model for ERa-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response

George Sflomos  –  Cancer Cell, 14 March 2016

Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk

Renuga Devi Rajaram  –  EMBO Journal, 4 March 2015

 

 

Progesterone/RANKL is a Major Regulatory Axis in the Human Breast

Tamara Tanos  –  Science Translational Medecine, 24 April 2013

Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development

Dalya Ataca  –  Biology Open, 13 Sept. 2016